Pharmacodynamic damamycin ke ea lithibela-mafu tsa aminoglycoside, 'me e na le phello e itekanetseng ea ho thibela likokoana-hloko tse fapaneng tsa gram-negative, tse kang escherichia coli, salmonella, shigella, proteus joalo-joalo. E na le kutloelo-bohloko ho streptococcus, pneumococcus, staphylococcus epidermidis le mycoplasma e 'ngoe (e kang mycoplasma gallinarum, mycoplasma turkey, mycoplasma synovialis, joalo-joalo). Hangata ha e na kutloelo-bohloko ho streptococcus viridis le staphylococcus aureus. Hangata e hanyetsana le pseudomonas aeruginosa le treponemas. Libaktheria tsa mala li hanyetsana haholo le megamycin, empa ha li bontše ho hanyetsana le streptomycin. Lincomycin e na le ts'ebetso e ntle ea antibacterial khahlano le libaktheria tsa anaerobic, joalo ka clostridium, peptococcus, peptostreptococcus, clostridium tetanus, clostridium perfringens le actinomyces tse ngata. Lincomycin e sebetsa haholo ho karolo ea 50s ea li-ribosomes tsa baktheria, tse amang motsoako oa protheine ka ho thibela katoloso ea ketane ea peptide.
Pharmacokinetics feela 7% ea lincomycin e kenngoa ka mor'a tsamaiso ea ka hare, empa e boloka khatello e phahameng ka har'a pampitšana ea gastrointestinal. Motsoako oa lithane tsa moriana o tlase ho feta oa serum concentration. Ha ho bonolo ho kenya cerebrospinal fluid kapa leihlo, 'me tekanyo e tlamang ea protheine ea plasma ha e phahame. Lithethefatsi tse ngata li ntšoa ka glomerular filtration ka sebopeho sa tsona sa pele. The bioavailability ea lincomycin ke 30% ~ 40% le ho monya hampe tsamaisong ea molomo. Sekhahla sa ho monya le palo ea lincomycin li ka fokotsoa ka phepo e tsoakiloeng. Likhoho li ile tsa fuoa 50mg ea sehlahisoa sena (se qhibilihisitsoeng ka metsing a nooang) ka kilogram ea boima ba 'mele ka matsatsi a 7. Nakong ea tlhahlobo, lincomycin ea plasma e fihlile ho 0.14 μ g/ml, athe daguanmycin e ne e le nyane haholo. Kamora matsatsi a 7 a tlhahlobo, e ile ea feta 0.1μg/ml.
1. E kopantsoe le lincomycin, e ka eketsa haholo ts'ebetso ea antibacterial khahlanong le mycoplasma le ho atolosa antibacterial spectrum.
2. Motsoako oa lithethefatsi tsa lincomycin le anticholinesterase o ka fokotsa katleho ea ho qetela.
3. E kopantsoe le erythromycin e na le phello e hanyetsanang.
Lithibela-mafu. Bakeng sa libaktheria tsa Gram-negative, baktheria ea Gram-positive le tšoaetso ea mycoplasma.
Seno se tsoakiloeng: 100g ea sehlahisoa sena se kopantsoe le metsi 200 ~ 300kg bakeng sa kolobe le 50 ~ 100kg bakeng sa khoho ka matsatsi a 3 ~ 5. Phepo e tsoakiloeng: 100g ea lijo tse tsoakiloeng 100kg bakeng sa likolobe le 50kg bakeng sa likhoho, e sebelisoang matsatsi a 5 ho isa ho a 7.
Jala tlhokomelo ea bophelo bo botle: Ho tloha matsatsing a 7 pele ho pelehi ho isa ho matsatsi a 7 ka mor'a ho beleha, 100g ea sehlahisoa sena e kopantsoe 100kg, kapa 200kg le metsi. Tlhokomelo ea bophelo bo botle ba likolobe: Pele le ka mor'a ho khoesoa le ka mor'a mokhahlelo, 100g kopanya 100kg, kapa 200kg ea metsi.
Ha ho litlamorao tse mpe tse bonoang ha li sebelisoa ho latela ts'ebeliso le litekanyetso tse behiloeng.
