10% Ente ea Iron Dextran

Pharmacodynamic iron ke karolo ea mantlha ea hemoglobin le myoglobin. Hemoglobin ke eona e tsamaisang oksijene liseleng tse khubelu tsa mali. Myoglobin ke moo lisele tsa mesifa li bolokang oksijene ho thusa ho e fa mesifa nakong ea boikoetliso. Boholo ba li-enzyme le lintlha tse amehang potolohong ea asiti ea tricarboxylic li na le tšepe kapa li sebetsa feela boteng ba tšepe. Ka hona, ntle le ho potlakisa ha hemoglobin synthesis, matšoao a amanang le khaello ea tšepe ea lisele le ts'ebetso e fokotsehileng ea li-enzyme tse nang le tšepe, joalo ka ho lieha ho hola, boitšoaro bo bobe le bofokoli ba 'mele, a ka lokisoa butle-butle ka mor'a hore tšepe e sebelisoe liphoofolong tse haelloang ke tšepe. Pharmacokinetic iron bakeng sa ente e kenngoa ka potlako ho feta tšepe ea molomo; ka mor’a ente ea intramuscular ea iron dextran, khatello ea mali e ile ea fihla sehlohlolong ka lihora tse 24-48, ’me molek’hule ea eona e ne e le kholoanyane. E ne e kenngoa ke lijana tsa lymphatic ebe e fetisetsoa maling, 'me mahloriso a mali a eketseha butle-butle; ka mor'a ho kenngoa ka methapong kapa methapong ea mali ho potoloha mali, e ba phagocytic 'me e qhibiliha hore e be tšepe le dextran ka mononuclear phagocytic cell system. Ka mor'a ho kenngoa, li-ion tsa tšepe li na le oxidized ho li-ion tsa ferric ke ceruloplasmin maling, ebe li tlama ho li-receptors tsa transferrin, li kenya lisele ka mokhoa oa pinocytosis bakeng sa lisele tsa hematopoietic, kapa li ipokelle ka mokhoa oa ferritin kapa hemosiderin sebeteng, spleen, mokong oa masapo le litsamaiso tse ling tsa mononuclear cell phago. Sekhahla se tlamang liprotheine se phahame ka hemoglobin, empa se na le myoglobin e tlase, li-enzyme le liprotheine tse tsamaisang tšepe, hammoho le ferritin kapa hemosiderin e tlase.