Pharmacodynamics enrofloxacin ke setlhare se sephara sa bactericidal bakeng sa liphoofolo tsa fluoroquinolone. E na le phello e ntle ho escherichia coli, salmonella, klebsiella, brucella, pasteurella, actinobacillus pleuropneumoniae, erysipelas, proteus, serratia marcescens, corynebacterium pyogenes, portococcus septicus, staphylococcus aureus, phello e fokolang ea mycoplasma, joalo-joalo. aeruginosa le streptococcus, le phello e fokolang ho libaktheria tsa anaerobic. E na le phello e hlakileng ea post-antibacterial ho libaktheria tse hlokolosi. Mokhoa o thibelang likokoana-hloko oa sehlahisoa sena ke ho thibela enzyme ea ho potoloha ha baktheria, ho kena-kenana le ho ikatisa ha DNA ea baktheria, ho ngoloa le ho lokisa recombination, libaktheria ha li khone ho hōla le ho ikatisa ka mokhoa o tloaelehileng ebe lia shoa.
Pharmacokinetics ho kenngoa ha intramuscular ea sehlahisoa sena ho potlakile ebile ho feletse, ka bioavailability ea 91.9% likolobe le 82% likhomo tsa lebese. E ajoa haholo liphoofolong 'me e ka kenya lisele le maro a' mele hantle, ntle le cerebrospinal fluid, motsoako oa lithethefatsi hoo e batlang e le liseleng tsohle o phahame ho feta oa plasma. Metabolism ea sebete haholo-holo ke ho hlahisa ciprofloxacin ka ho tlosa ethyl ea 7-piperazine reng, e lateloe ke oxidation le glucuronic acid e tlamang. Haholo-holo e ntšoa ke liphio (ka secretion ea renal tubule le glomerular filtration), 'me 15% ho isa ho 50% e ntšoa ho tsoa morong ka mokhoa oa eona oa pele. Ho felisoa ha halofo ea bophelo ho fapana haholo ka mefuta e fapaneng le litsela tse fapaneng tsa tsamaiso. Ho felisoa ha halofo ea bophelo ka mor'a ente ea intramuscular ke lihora tse 5,9 ho likhomo, lihora tse 9,9 lipere, lihora tse 1.5 ho isa ho tse 4.5 ho linku, le lihora tse 4,6 likolobe.
1. Sehlahisoa sena se na le phello ea synergistic ha se sebelisoa le aminoglycoside kapa penicillin e pharaletseng.
2. Li-ion tsa tšepe tse boima tse kang ca2+, mg2+, fe3+ le al3+ canchelate ka sehlahisoa sena 'me li ama ho monya.
3. Ha e kopantsoe le theophylline le caffeine, e ka fokotsa sekhahla se tlamang sa protheine ea plasma, ka tsela e sa tloaelehang ea eketsa mahloriso a theophylline le caffeine maling, esita le ho hlaha matšoao a chefo ea theophylline.
4. Sehlahisoa sena se na le phello ea ho thibela li-enzyme tsa lithethefatsi tsa sebete, tse ka fokotsang sekhahla sa ho tlosoa ha lithethefatsi haholo-holo tse entsoeng ka metabolized sebeteng le ho eketsa khatello ea meriana ea mali.
Lithethefatsi tsa antibacterial tsa fluoroquinolone. E sebelisoa bakeng sa mafu a baktheria a liphoofolo le likhoho le tšoaetso ea mycoplasma.
Ente e ka har'a mesifa: Tekanyetso e le 'ngoe, 0.025ml ka 1kg boima ba' mele ba likhomo, linku le likolobe; 0.025 ~ 0.05ml bakeng sa lintja, likatse le mebutlanyana. Sebelisa makhetlo a 1 ho isa ho a 2 ka letsatsi bakeng sa matsatsi a 2 ho isa ho a 3.
1. Ho senyeha ha lefufuru ho liphoofolo tse nyenyane, ho ama tsoelo-pele ea masapo le ho baka ho holofala le bohloko.
2. Karabelo ea tsamaiso ea tšilo ea lijo e kenyelletsa ho hlatsa, ho lahleheloa ke takatso ea lijo, letšollo le kapele.
3. Boitšoaro ba letlalo bo kenyelletsa erythema, pruritus, urticaria le photosensitivity.
4. Matšoao a ho kula, ataxia, ho tsieleha ho bonoa ho lintja le likatse.
1. E na le phello e ka hlasimollang tsamaisong e bohareng, e bakang lefu la sethoathoa, 'me e lokela ho sebelisoa ka hloko ho lintja tsa sethoathoa.
2. Liphoofolo tse jang nama le liphoofolo tse sa sebetseng hantle liphio li lokela ho sebelisoa ka hloko, e leng seo ka linako tse ling se ka bakang moroto oa kristale.
3. Sehlahisoa sena ha sea lokela lipere. Liente tsa intramuscular ke li-irritants tsa nakoana.
4. Sehlahisoa sena ha sea lokela ho sebelisoa ho lintja pele ho libeke tse 8 tsa lilemo.
5. Mefuta e hanyetsanang le lithethefatsi ea sehlahisoa sena e ntse e eketseha 'me ha ea lokela ho sebelisoa ka tekanyo ea subtherapeutic nako e telele.
